The Brilliant Little Weight Loss Capsule
The Epitomee® Capsule is a prescription only, drug-free support tool to facilitate
weight loss. It helps
you
feel full sooner, eat less, and stay on track—without stimulants, hormones, or surgical procedures.
I want to feel amazing in my dress, without crash diets or calorie counting.
I’ve tried everything, even GLP-1s, but nothing has worked for me.
Since entering perimenopause, what used to work no longer does.
I’m done with synthetic fixes. I want to lose weight in a healthy, natural way.
HOW IT WORKS
Redefining Weight Loss with
Science and Simplicity
Each Epitomee® Capsule contains a proprietary polymer blend that gently expands in the stomach after being taken with water, forming a semi-rigid, gel-like triangle structure. This structure creates a feeling of fullness, signaling the brain to help you feel satiety, so you can eat smaller portions and fewer snacks between meals without feeling deprived.
See The BenefitsIS EPITOMEE RIGHT FOR YOU?
Is This Weight Management
Capsule Right for You?
A short quiz to explore how this drug-free capsule can support portion control and weight management.
Epitomee® is a prescription medical device and should be taken under the supervision of a healthcare provider.
Take The Quiz
TESTIMONIALS
The Epitomee® Capsule is a safe* and efficacious tool to be used as an adjunct to lifestyle intervention to promote weight loss.
Donna Ryan, MD
Professor Emerita at Pennigton Biomedical Research Center
See All TestimonialsClinical Results
Key Clinical Findings from
Trials with Lifestyle Coaching
See The Results
Epitomee® has undergone a series of rigorous clinical studies to evaluate its safety and effectiveness as a non-drug weight management solution. These trials have demonstrated meaningful weight loss, improved appetite control, and favorable tolerance among diverse patient populations. The data supports the Epitomee® Capsule’s unique approach to portion control and sustainable** weight reduction, helping individuals take control of their health with a simple, science-backed intervention.
2–3 in
Lost off waistline over 24 weeks1
9.3%
Average weight loss at 24 weeks for early responders2
60%
Reversed Metabolic Syndrome at 24 weeks3
Epitomee® Capsule
Which Patients Are Appropriate Candidates?
Epitomee® is indicated for weight management in overweight adults with a BMI of 25-40 kg/m², when used in conjunction with diet and physical activity.
See further detailed information in the Epitomee® Capsule instruction of use, including contraindications and precautions sections.
- Individuals who want a non-drug, non-surgical approach.
- Individuals who experienced GLP-1 intolerance.
- Individuals seeking other weight management options after completing medication-based interventions.
- Individuals who struggle with portion control or early satiety and have had little success with diet and exercise.
- Individuals without comorbidities who don’t qualify for GLP-1 medications. It fills the gap for lower-BMI patients underserved by current treatments.
Drug-Free Technology That Works
The Epitomee® Capsule represents a new frontier in weight management—combining advanced material science with a simple, natural mechanism of action. Each Capsule contains a proprietary polymer blend that gently expands in the stomach after being taken with water, forming a semi-rigid, gel-like triangle structure. Here’s how it works.
INGESTING
Swallow one capsule with two 8-ounce (250 ml) glasses of water, 30 minutes before lunch and dinner.
EXPANDING
Once in your stomach, the device inside the capsule absorbs the water and gently expands into a triangle shape.
SATIATING
The expanded triangle gently presses on your stomach walls, signaling fullness to your brain.
DISINTEGRATING
After several hours, the capsule breaks down completely in the small intestine and is naturally cleared out of the body.
QUALITY STANDARDS
Built on Science,Backed by Safety
Epitomee is manufactured in state-of-the-art facilities under strict quality controls that meet medical device manufacturing standards. Our products undergo rigorous testing to ensure safety, consistency, and reliability, so you can feel confident in what you’re putting into your body.
Our Quality StandardsSimple to Integrate Into Your Practice
Dosing
Take one capsule, twice daily with two cups of water (250ml), 30 minutes before lunch and dinner.
Program
The Epitomee® treatment is indicated for use alongside diet and physical activity.
Monitoring
Routine follow-ups help support behavior change and track progress effectively.
Prescribed Access
Available through select healthcare providers or specialty pharmacies.
Redefining Weight Management
with Science and Simplicity
The Epitomee® Capsule offers your patients a manageable, prescription-only solution for achieving and maintaining a healthier weight—without the risks associated with pharmacologic treatments.
For patients who have struggled with portion control, GLP-1 intolerance,
or weight rebound,
the Epitomee® Capsule offers a science-backed
solution to help reduce caloric intake while
supporting lifestyle changes.
A Novel Technology
Science-based capsule mimics food with no stimulants, no strict diets—just appetite control for patient success.
Non-Drug Alternative
A clinically proven, safe, non-pharmacological approach to portion control and appetite regulation.
Filling the Treatment Gap
Ideal for patients who aren’t ready/eligible for medication or surgery but need more than lifestyle changes alone.
Simplicity & Adherence
Easy-to-use dosing supports adherence without complex routines or behavioral exhaustion.
Clinical Results for Safe, Long-Term Weight Loss
Choose a category below to explore our specialized services.
Predictable Weight Loss
Early Responders Lost 9.3% of Their Body Weight Over 24 Weeks
Early weight loss with Epitomee® treatment (losing at least 2% at week 8) resulted in an average weight loss of 9.3% within 24 weeks.
*** p<0.001 Epitomee® versus placebo early responders
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Sustainable Results
11.2% Body Weight Lost Over 48 Weeks in Extension Study
Participants who completed 24 weeks of Epitomee® treatment and lost at least 3% joined the extension study for another 24 weeks. They had lost 11.3% of baseline body weight after 24 weeks.
With 24 additional weeks of Epitomee® plus lifestyle counseling, participants maintained a total 11.2% loss at week 48.
Those on placebo lost 6.0% after 24 weeks. After switching to the Epitomee® capsule, they lost an additional 1.5% over the next 24 weeks.
**p<0.01; ***p<0.001
Low Risk
Zero Related Serious Adverse Events
The Epitomee® Capsule is designed to provide effective results with a favorable safety profile. Adverse events reported by participants were similar between Epitomee® and placebo groups.
This indicates that Epitomee® treatment has no apparent side effects or related serious adverse events.
Inquiry Now
Clinical Results for Improved Health Conditions
Helps Reduce the Risk of Metabolic Syndrome4
Weight Loss with the Epitomee® Capsule can potentially improve glycemic control and other cardiometabolic risk factors, contributing to improved overall health.
Of the 27 participants in the Epitomee® Capsule group with MetS at baseline, 16 (60%) no longer had 3 or more diagnostic components of the MetS at week 24. Among participants with MetS, those taking the Epitomee® Capsule lost significantly more weight than those on placebo. (8.3% vs. 5.2%; p < 0.0004).
Clinical Results for Improved Health Conditions
Helps Reduce the Risk of Diabetes4
Weight loss in study participants with prediabetes was associated with significant improvements in insulin levels and insulin resistance (HOMA-IR) within 24 weeks, reducing their risk of developing diabetes compared to those receiving a placebo.
p < 0.01
Clinical Results for Improved Well-Being
Experience Measurable Improvement In Quality of Life5
Weight loss in both Epitomee® participants and placebo significantly improved their quality of life from baseline (# p < 0.05). However, compared to placebo, the Epitomee® Capsule group exhibited significantly greater improvements in Physical Function and IWQOL-Lite-CT total scores (*p < 0.05).
Trusted by Clinicians
Backed by Experts in Weight Management
I’m especially excited about Epitomee as an option for patients who struggle with hunger control at specific times of the day…
Dr. Angela GoldenFamily Nurse Practitioner
Epitomee offers a flexible, safe, and well-tolerated weight management solution suitable for a wide range of patients…
Professor Srivastava Gitanjali, MDMedical Director, Vanderbilt University School of Medicine
I see the Epitomee capsule as an important tool in my toolbox due to its promising weight management treatment…
Tonya F. TurnerDietitian, University of South Carolina
Epitomee® – Questions & Answers
• Contains no active pharmaceutical ingredients
• Has no effect on metabolism or hormones
• Does not suppress appetite chemically
• Works through physical satiety
• Pregnant or breastfeeding women
• Individuals with certain gastrointestinal conditions
• Patients with swallowing disorders
Medical consultation is required before use.
ARTICLES
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